Assessment of the liver biochemical status of carpenters occupationally exposed to wood dust in Enugu metropolis South-East Nigeria.
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Abstract
Liver disease has a global distribution and ranks as the twelfth leading cause of mortality. This cross-sectional study carried out between June and November 2021 aimed to assess the liver biochemical status of carpenters occupationally exposed to wood dust in Enugu metropolis South-east Nigeria. The Ethical Committee of the University of Nigeria Teaching Hospital in Enugu gave its approval. A total of one hundred and twenty-four (124) participants; sixty-two (62) carpenters (exposed) and sixty-two (62) age and sex-matched (males) control (unexposed) were recruited for this study. Study participants were chosen by simple random sampling. Spectrophotometric method was used to test participants’ blood samples for liver enzymes alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP). A statistically significant increase (p<0.05) was observed in the liver biochemical enzymes of the carpenters (exposed) in comparison to the controls (unexposed). The carpenters do not use any form of personal protective equipment (90.32%) or have a good knowledge of any occupational risk (83.87%) they are exposed to. A statistically significant positive correlation (p<0.05) was observed between ALT, AST and ALP enzyme activity and the duration of exposure to wood dust (in years) of the exposed. This study suggests that occupational exposure to wood dust may cause metabolic changes in the Liver. Constant use of personal protective equipment when at work, personal hygiene and regular health check is recommended.
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