The Effect of Soya bean ( Glycine max) on Pefloxacin Absorption in Rats
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Abstract
The study was to investigate the effect of soya bean on the absorption of pefloxacin when given by oral route in rats. The first group of animals feeding on standard pellet feeds was given pefloxacin (8 mg/kg, p.o), while the second and third groups were also given the drug at the same dosage level but were fed with 50 % and 100 % soya bean respectively. Plasma samples were collected at different time intervals following drug administration. The concentrations of pefloxacin in plasma were determined using spectrophotometric method. Feeds with 50 % and 100 % soya bean respectively, gave significant increase (P<0.05) in the mean maximum plasma concentration (Cmax), mean area under the plasma concentration-time curve (AUC) compared to those obtained for standard pellet feeds alone. No significant change in the mean time to reach maximum concentration (T max) was observed in all the tests. The results suggest an increase in the total absorption of pefloxacin by soya bean.
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References
Chasseaud, L. F, Taylor, T (1974). Bioavailability of drugs from formulations after oral administration. Ann Rev Pharmacol, 14: 35-46.
Gibaldi, M. , Feldman, S. (1970) Mechanism of surfactant effects on drug absorption. J Pharm Sci, 59 (5) : 579-589.
Hooper, D. C. (1999). Mode of action of fluoroquinolones. Drugs, 58(2): 6-10.
Jefferson, J. W (1998). Drug and Diet interactions : Avoiding therapeutic paralysis. J. Clin. Psych, 59 (16) : 3-9
Kirk, J. T (1995). Significant drug-nutrient interactions. Am Fam Physcian, 51 (5) : 1175-1177.
Leibovitch, E. R., Deamer, R. L, Sanderson, L. A (2004). Food-Drug interactions ; Careful drug selection and patient councelling can reduce the risk in older patients. Geriatrics, 59: 19 – 33.
Levine, R. (1970). Factors affecting gastrointestinal absorption of drugs. Am J Digest Dis, 15: 171 – 180.
Levy, G. (1972). Bioavailability, clinical effectiveness and the public interest. Pharmacol, 8: 33 – 43.
Melander, A. (1978). Influence of food on the bioavailability of drugs. Clin Pharmacokin, 3: 337-351.
Montay, G., Goueffon, Y Rouquet, F (1984). Absorption, distribution, metabolic fate and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys and humans. Antimicrob Agents Chemother, 25: 463-472.
Sorg, D. A, Buckner, B (1964). A simple method of obtaining venous blood from small laboratory animals. Proc Soc Exp Biol Med, 115: 1131-1132.
Toothhaker, R. D , Welling, P. G (1980). The effect of food on drug bioavailability. Ann Rev Pharmacol Toxicol, 20: 173 – 199.
Ulrich, J, Fritz, S, Ulrich, S, Walter, S (1994). Effect of an antacid containing Mg and Al on absorption, metabolism and mechanism of renal elimination of pefloxacin in humans. Antimicrob Agents Chemother, 38 (5): 1129-1133.
Welling, P. G. (1977). Influence of food and diet on gastrointestinal drug absorption: A review. J Pharm Biopharm, 5: 291 – 234.