A Study of the Potential Interaction of Valsartan with some Electrolytes
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Abstract
The effect of electrolytes (salts) on the partition coefficient of valsartan was studied at room temperature. The investigation was done by partitioning valsartan between 1-octanol and electrolyte solutions of varying concentrations. It was found that all the electrolytes increased the partition coefficient of the drug except sodium fluoride. The effect was found to depend on the size and charge of the ions present in solution.
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