Study on the Solubilization of Sparfloxacin by Aqueous Cosolvent and Micellar Solutions
Main Article Content
Abstract
The effect of ethanol, glycerol, propylene glycol, polysorbate-80 and sodium lauryl sulfate on the aqueous solubility of sparfloxacin was studied. It was found that all these substances increase the aqueous solubility of the drug. Of the solubilizing agents used, sodium lauryl sulfate was observed to be the most effective. The increase was in the following order: sodium lauryl sulfate > polysorbate-80 > propylene glycol > glycerol
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Alkhamis, K. A., Allaboun, H. and Al-Momani, W. Y. (2000). Study of the solubilization of gliclazide by aqueous micellar solutions. J. Pharm. Sci., 92: 839-846.
Feldman, S. and Gibaldi, M. (1967). Effect of urea on solubility. Role of water structure. J. Pharm. Sci., 56: 370-375.
Hooper, D. C. (1999). Mode of action of fluoroquinolones. Drugs, 58(2): 6 -10.
Khalil, E., Nuijai, S. and Silam, A. (2000). Aqueous solubility of diclofenac diethylamine in the presence of pharmaceutics additives: a comparative study with diclofenac sodium. Drug Dev. Ind. Pharm., 26: 375-381.
Mbah, C. J. (2006). Solubilization of valsartan by aqueous glycerol, polyethylene glycol and micellar solutions. Pharmazie, 6: 322 - 324.
Powel, M.F., Nguyen, T. and Baloian, L. (1998). Compendium of excipients for parenteral formulations. PDA J. Pharm. Sci. Technol., 50: 238-311.
Varia, S. A., Faustino, M.M., Thakur, A. B., Clow, C. S. and Serajuddin, A.T. (1991). Optimization of cosolvent concentration and excipient composition in a topical corticosteroid solution. J. Pharm. Sci. 80: 872-875.
Yalkowsky, S. H. (1999). Solubility and solubilization in aqueous media; Oxford University Press, New York.
Zhao, L., Li, P. and Yalkowsky, S. H. (1999). Solubilization of fluasterone. J. Pharm. Sci. 88: 967-969.