Chromatographic Separation of Some Antiemetics on Silica Gel-Surfactant Impregnated Thin-Layer Plates
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Abstract
A thin layer chromatographic (TLC) separation of five antiemetic agents on silica gel-surfactant impregnated plates using a mixture of ethanol-water-acetic acid (40:50:10) as developing system was studied. The visualization of the spots was done by exposure of the plates to iodine vapour. Of the two surfactants employed (polysorbate-80 and sodium lauryl sulfate) at various concentrations, sodium lauryl sulfate at 1.25% w/v concentration level exhibited the best separation ability.
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